Reproducible Candidate Prioritization with Evolving Gene Maps
Abstract
The boundary between useful assistance and an unsupported claim becomes visible when new annotations altering conclusions without a version trail. A bounded review of the literature is used to formulate, rather than claim to complete, an evaluation. The primary literature contributes a bounded result: only the supplied bibliographic scope supports discussion here; specific cohorts, variants, effect sizes, datasets, and analysis algorithms remain unverified. A revision changes what later readers see and can also change what earlier decisions appear to have known. Versioning must preserve both reproducibility and correction. Maintain decision-time and latest versions separately. Record the reason for each revision and test whether past results can be reproduced without future information. The proposed comparison concerns gene annotations, reference builds, tissue maps; it would test whether the specific failure scenario is detected without erasing legitimate uncertainty. An integrated account should preserve the distinction between candidate regions and cellular annotations and any stronger downstream decision.
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