Iterative Critique of Therapeutic Resistance Narratives
Abstract
Iterative Critique of Therapeutic Resistance Narratives addresses a narrow but consequential interpretive problem: a plausible sequence of mechanisms lacking direct linkage. The article develops a research agenda through critical comparison of published evidence. The focal evidence concerns why autoimmune activity can persist or recur when conventional inflammation suppression does not durably change underlying cellular and tissue states. A chain of individually plausible statements can contain an unsupported transition. The gap may lie between exposure and pathway, pathway and state, or state and outcome. Audit every transition and attach its actual support. Mark unmeasured links explicitly and prioritize a test that could break the chain. The proposed comparison concerns neutrophil states, metabolic persistence, treatment resistance; it would test whether the specific failure scenario is detected without erasing legitimate uncertainty. Implications are restricted to the evidence roles relevant to immune-state and tumor evidence synthesis, leaving broader efficacy and deployment claims unresolved.
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